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Clinical Observation |

Treatment of a Bowenoid Papulosis of the Penis With Local Applications of Cidofovir in a Patient With Acquired Immunodeficiency Syndrome

Robert Snoeck, MD, PhD; Yves Van Laethem, MD; Erik De Clercq, MD, PhD; Josiane De Maubeuge, MD; Nathan Clumeck, MD, PhD
Arch Intern Med. 2001;161(19):2382-2384. doi:10.1001/archinte.161.19.2382.
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We report a case of bowenoid papulosis in a patient with acquired immunodeficiency syndrome that was successfully treated with local applications of cidofovir in Beeler base. This treatment should be confirmed as a valuable nonagressive therapy for such potentially invasive viral-induced cell proliferation.

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Link to Article[[XSLOpenURL/10.1002/(ISSN)1097-0142]]
Su  CKShipley  WU Bowenoid papulosis: a benign lesion of the shaft of the penis misdiagnosed as squamous carcinoma. J Urol. 1997;1571361- 1362
Link to Article[[XSLOpenURL/10.1016/S0022-5347(01)64981-4]]
Bhojwani  ABiyani  CSNicol  APowell  CS Bowenoid papulosis of the penis. Br J Urol. 1997;80508
Link to Article[[XSLOpenURL/10.1046/j.1464-410X.1997.00389.x]]
De Clercq  E Therapeutic potential of cidofovir (HPMPC, Vistide) for the treatment of DNA virus (i.e. herpes-, papova-, pox- and adenovirus) infections. Verh K Acad Geneeskd Belg. 1996;5819- 49
Snoeck  RNoel  J-CMuller  CDe Clercq  EBossens  M Cidofovir, a new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III). J Med Virol. 2000;60205- 209
Link to Article[[XSLOpenURL/10.1002/(ISSN)1096-9071]]
Snoeck  RVan Ranst  MAndrei  G  et al.  Treatment of anogenital papillomavirus infections with an acyclic nucleoside phosphonate analogue. N Engl J Med. 1995;333943- 944
Link to Article[[XSLOpenURL/10.1056/NEJM199510053331418]]
Snoeck  RBossens  MParent  D  et al.  A double-blind placebo-controlled study of cidofovir gel for human papillomavirus (HPV)-associated genital warts [abstract]. Antiviral Res. 1998;37A47
Link to Article[[XSLOpenURL/10.1016/S0166-3542(97)00056-9]]
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Figure 1.

Time line of treatment. HIV indicates human immunodeficiency virus.

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Figure 2.

Lesion before treatment.

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Figure 3.

Lesion after first application.

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Figure 4.

Lesion 2 months after initiation of treatment.

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