We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Fluconazole and Candida krusei Fungemia

Corrado Girmenia, MD; Livio Pagano, MD; Giuseppe Leone, MD; Pietro Martino, MD
Arch Intern Med. 2001;161(18):2269-2270. doi:.
Text Size: A A A
Published online


In their series on Candida krusei fungemia occurring at The University of Texas M. D. Anderson Cancer Center, Houston, from 1989 to 1996, Abbas et al1 observed an escalating frequency of this complication in patients with hematologic malignancies since 1993, when fluconazole became widely used as a prophylactic agent. These data confirm the association between fluconazole use and infections caused by this fungus that was previously reported at The University of Texas M. D. Anderson Cancer Center.2 However, this epidemiologic phenomenon continues to be debated, as other authors have not observed an impact of fluconazole use on the etiology of Candida infections, and the proportion of patients with cancer and candidemia due to C krusei seems not to have varied over the past 2 decades.39 Importantly, the emergence of C krusei infections in association with fluconazole prophylaxis has been noted only at single centers,1,1013 in contrast with the findings in multicenter trials.35

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption

Use of oral and intravenous fluconazole and number of Candida krusei fungemia episodes at the Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza" (A), and the Istituto di Semeiotica Medica, University Cattolica del Sacro Cuore (B), Rome, Italy.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections