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Primary Infection With a Multidrug-Resistant HIV-1 Strain

Sophie Morelon, MD; Martine Harzic, MD; Marie-Laure Chadenat, MD; Caroline Dupont, MD; Elisabeth Rouveix, MD
Arch Intern Med. 2001;161(18):2259-2260. doi:.
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Drug resistance may be the main cause of antiretroviral treatment failure in human immunodeficiency virus (HIV) infection. Drug-resistant mutations have been described for all 3 classes of antiretroviral drugs. The first case of sexual transmission of a multidrug-resistant variant (MDR) was published in 1998.1 We report a new case.

Hecht  FMGrant  RMPetropoulos  CJ  et al.  Sexual transmission of an HIV-1 variant resistant to multiple reverse transcriptase and protease inhibitors. N Engl J Med. 1998;339307- 311
Ngo-Giang-Huong  NDeveau  CDa Silva  I  et al.  Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy. AIDS. 2001;151- 9
Boden  DHurley  AZhang  A  et al.  HIV-1 drug resistance in newly infected individuals. JAMA. 1999;2821135- 1141
Little  SJDaar  ESD'Aquila  RT  et al.  Reduced antiretroviral drug susceptibility among patients with primary HIV infection. JAMA. 1999;2821142- 1149
Tamalet  CPasquier  CYahi  N  et al.  Prevalence of drug-resistant mutants and virological response to combination therapy in patients with primary HIV-1 infection. J Med Virol. 2000;61181- 186
Yerly  SKaiser  LRace  EBru  J-PClavel  FPerrin  L Transmission of antiretroviral-drug-resistant HIV-1 variant. Lancet. 1999;354729- 733

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