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Erythema Multiforme Associated With Bupropion Use

Rodolfo Carrillo-Jimenez, MD; Matthew Zogby, MD; Thomas L. Treadwell, MD
Arch Intern Med. 2001;161(12):1556. doi:.
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Bupropion (Wellbutrin; Glaxo Welcome Inc, Triangle Park, NC) is a popular antidepressant commonly used for the treatment of nicotine addiction. Common adverse effects include dose-related seizure disorders and other neuropsychiatric disturbances.1 A search of the literature did not disclose any published work linking the use of bupropion with the development of erythema multiforme.

Not Available, Physicians' Desk Reference.  Montvale, NJ Medical Economics Co2000;1301- 1308
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Kimyai-Asadi  AHarris  JNousari  HC Critical overview: adverse cutaneous reactions to psychotropic medications. J Clin Psychiatry. 1999;60714- 725
Kaplan  AP Drug-induced skin disease. J Allergy Clin Immunol. 1984;74 ((4, pt 2)) 573- 579
Delafuente  JC Drug-induced erythema multiforme: a possible immunologic pathogenesis. Drug Intell Clin Pharm. 1985;19114- 117
Amichai  BGrunwald  MH Erythema multiforme due to clonazepam: supportive evidence from macrophage inhibition factor test. Clin Exp Dermatol. 1998;23206- 207
Perdu  DLavaud  FPrevost  A  et al.  Case report: erythema multiforme due to pyrazinamide. Allergy. 1996;51340- 342
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Erythema multiforme on the skin of the back and right shoulder.

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