THE ARTICLE by Cui et al1 reports that non–high-density lipoprotein cholesterol (non–HDL-C) is a somewhat better predictor of cardiovascular disease mortality than is low-density lipoprotein cholesterol (LDL-C) in the Lipid Research Clinics Follow-up Study. The authors note that the National Cholesterol Education Program (NCEP) has identified LDL-C as the primary target of therapy for lowering cholesterol levels.2,3 However, if non–HDL-C level is a better predictor of cardiovascular disease than is LDL-C level, perhaps non–HDL-C should replace LDL-C in risk prediction and should be the primary target of therapy for lowering cholesterol levels.
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