0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Periodontal Disease, C-Reactive Protein, and Ischemic Stroke

Mario Di Napoli, MD; Francesca Papa, MD; Vittorio Bocola, MD
Arch Intern Med. 2001;161(9):1234. doi:.
Text Size: A A A
Published online

Extract

Wu et al1 have shown that periodontal disease is another putative and independent risk factor for cerebrovascular disease, particularly for ischemic stroke. Presently, it is unknown whether the association between periodontal disease and stroke is causal. Several pathogenic pathways make a causal linkage possible. Beck at al2 hypothesized that subjects with genetically determined strong monocytic response to bacterial antigens could be at high risk for developing both periodontal disease and atherosclerosis. It is also possible that a susceptibility to strong inflammatory response could increase the risk of both periodontitis and stroke. Inflammation in the vessel wall plays an essential role not only in the initiation and progression of atherosclerosis but also in the erosion or fissuration of plaques and eventually in the rupture of plaques.3

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Probability of death within 1 year according to different patterns of changes in serum c-reactive protein levels from admission through discharge. The patients were grouped according to different patterns of c-reactive protein levels from admission to discharge. Group 1 indicates a persistently normal pattern (n = 34 [17.6%]); group 2, an increasing pattern (n = 13 [6.8%]); group 3, a decreasing pattern (n = 57 [29.5%]); and group 4, a pattern of persistent elevation (n = 89 [46.1%]) (log-rank test, P<.001; χ2 test for trend, P<.001). The risk of death at 1 year was derived from Kaplan-Meier curves. The risk was 2.2% (95% confidence interval [CI], 0.3%-13.8%) for patients with a persistently normal pattern; 20.0% (95% CI, 6.6%-47.1%) for those with an increasing pattern; 0% (95% CI, 0%-6.3%) for those with a decreasing pattern; and 27.8% (95% CI, 19.6%-37.9%) for those with a pattern of persistent elevation.

Graphic Jump Location

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 8

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
JAMAevidence.com

Users' Guides to the Medical Literature
Table 9.2-3 Refuted Evidence From Observational Studiesa

The Rational Clinical Examination
Quick Reference

brightcove.createExperiences();