0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Buerger Disease or Arsenic Intoxication?

Bernard Noël, MD
Arch Intern Med. 2001;161(7):1016. doi:.
Text Size: A A A
Published online

Extract

I read with interest the clinical observation of Marder and Mellinghoff1 regarding the possible association between Buerger disease and cocaine. Many epidemiological and toxicological studies are converging to demonstrate that Buerger disease may be related to arsenic intoxication. These interesting data are presented here.

Buerger disease is rare in Western countries but is the most prevalent vascular disease in Southeast Asia. Smoking is generally considered the principal cause. However, nonsmokers are sometimes also affected. In Western countries, the incidence of Buerger disease has been declining since 1947, but curiously not the rate of mortality due to cigarette smoking.2,3 In several Asian countries, such a decline in the incidence of Buerger disease has not occurred. In Taiwan, blackfoot disease (an endemic form of vascular thrombosis similar to Buerger disease) is related to arsenic poisoning from well water.4 The same public health problem is present in Bangladesh and in some areas of India where almost half of the population is at risk of arsenic intoxication.5,6 This could explain the high prevalence of Buerger disease in these regions. Toxicological and histological studies tend to confirm this pathological relationship.7

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Buerger disease or arsenic intoxication? Arch Intern Med 2001;161(7):1016.
Jobs
brightcove.createExperiences();