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Pituitary Gangliocytoma-Adenoma Presenting With Acromegaly: Response to Treatment

Victoria Luna, MD; Francisco Morales, MD; Luis M. Luengo, MD; Angel Sanz, MD; Jose Diaz, MD
Arch Intern Med. 2001;161(7):1010-1011. doi:.
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Acromegaly is the clinical syndrome that results from excessive secretion of growth hormone (GH). The most common cause of acromegaly is a somatotroph (GH-secreting) adenoma of the anterior pituitary gland. In rare cases, overproduction of GH-releasing hormone (GHRH) by functional hypothalamic tumors such as hamartomas and gangliocytomas may cause acromegaly by inducing proliferation of GH-secreting pituitary cells.1 However, to our knowledge, few cases of combined pituitary adenoma and sellar gangliocytoma presenting with acromegaly have been reported.2

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