We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comments, Opinions, and Brief Case Reports |

Adult-Onset Type 1 Diabetes With DIDMOAD Syndrome–like Manifestations

Michiaki Fukui, MD; Yoshihiro Kitagawa, MD; Naoto Nakamura, MD; Toshikazu Yoshikawa, MD
Arch Intern Med. 2001;161(5):767-769. doi:.
Text Size: A A A
Published online


DIDMOAD syndrome is defined by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.1 It is inherited as an autosomal recessive trait with varying expressivity. We report an interesting case involving a patient with type 1 diabetes with DIDMOAD syndrome–like manifestations.

Page  MMCBAsmal  ACEdwards  CRW Recessive inheritance of diabetes: the syndrome of diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Q J Med. 1976;45505- 520
Najjar  SSSaikaly  MGZaytoun  GMAbdelnoor  A Association of diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Arch Dis Child. 1985;60823- 828
Link to Article[[XSLOpenURL/10.1136/adc.60.9.823]]
Kinsley  BTSwift  MDumont  RHSwift  RG Morbidity and mortality in the Wolfram syndrome. Diabetes Care. 1995;181566- 1570
Link to Article[[XSLOpenURL/10.2337/diacare.18.12.1566]]
Niakanen  LKTuomi  TKarjalainen  JGroop  LCUusitupa  MIJ GAD antibodies in NIDDM. Diabetes Care. 1995;181557- 1565
Link to Article[[XSLOpenURL/10.2337/diacare.18.12.1557]]
Shimada  AImazu  YMorinaga  S  et al.  T-cell insulitis found in anti-GAD65+ diabetes with residual β-cell function. Diabetes Care. 1999;22615- 617
Link to Article[[XSLOpenURL/10.2337/diacare.22.4.615]]
Monson  JPBoucher  BJ HLA type and islet cell antibody status in family with DIDMOAD syndrome. Lancet. 1983;11286- 1287
Link to Article[[XSLOpenURL/10.1016/S0140-6736(83)92746-0]]
Fukui  MNakano  KNakamura  N  et al.  HLA-DRB 1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase. J Clin Immunol. 1998;1889- 92
Link to Article[[XSLOpenURL/10.1023/A:1023248106674]]

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Diabetes, Foot Ulcer

Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
Clarifying Your Question