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Adult-Onset Type 1 Diabetes With DIDMOAD Syndrome–like Manifestations

Michiaki Fukui, MD; Yoshihiro Kitagawa, MD; Naoto Nakamura, MD; Toshikazu Yoshikawa, MD
Arch Intern Med. 2001;161(5):767-769. doi:.
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DIDMOAD syndrome is defined by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.1 It is inherited as an autosomal recessive trait with varying expressivity. We report an interesting case involving a patient with type 1 diabetes with DIDMOAD syndrome–like manifestations.

Page  MMCBAsmal  ACEdwards  CRW Recessive inheritance of diabetes: the syndrome of diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Q J Med. 1976;45505- 520
Najjar  SSSaikaly  MGZaytoun  GMAbdelnoor  A Association of diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Arch Dis Child. 1985;60823- 828
Kinsley  BTSwift  MDumont  RHSwift  RG Morbidity and mortality in the Wolfram syndrome. Diabetes Care. 1995;181566- 1570
Niakanen  LKTuomi  TKarjalainen  JGroop  LCUusitupa  MIJ GAD antibodies in NIDDM. Diabetes Care. 1995;181557- 1565
Shimada  AImazu  YMorinaga  S  et al.  T-cell insulitis found in anti-GAD65+ diabetes with residual β-cell function. Diabetes Care. 1999;22615- 617
Monson  JPBoucher  BJ HLA type and islet cell antibody status in family with DIDMOAD syndrome. Lancet. 1983;11286- 1287
Fukui  MNakano  KNakamura  N  et al.  HLA-DRB 1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase. J Clin Immunol. 1998;1889- 92

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