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Intranasal Tranexamic Acid Treatment for Severe Epistaxis in Hereditary Hemorrhagic Telangiectasia

Abraham Klepfish, MD; Alain Berrebi, MD; Ami Schattner, MD
Arch Intern Med. 2001;161(5):767-769. doi:.
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Hereditary hemorrhagic telangiectasia (HHT [Osler-Rendu-Weber disease]) is a dominantly inherited disease characterized by multiple telangiectatic lesions or arteriovenous malformations that may rupture and bleed. Symptoms vary according to the location of the lesions, but the skin, nasal mucosa, gastrointestinal tract mucosa, and pulmonary, cerebral, or hepatic circulation are commonly affected.1 The prevalence of HHT in Europe is 14 to 16 persons per 100 000 and may be rising. Epistaxis is both an early and very common manifestation of HHT affecting most patients and is often recurrent, severe, and resistant to treatment.2 We report a simple, safe, and efficacious treatment for recurrent severe epistaxis in HHT.

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