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Comments, Opinions, and Brief Case Reports |

Digital Gangrene and a Mass in the Heart

W. Y. Au, MRCP; M. H. Jim, MRCP; K. Y. Lam, FRACP; Y. L. Kwong, MD
Arch Intern Med. 2001;161(2):292-293. doi:.
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Mixed connective tissue disease (MCTD) is an autoimmune disease with features comparable with systemic lupus erythematosus, scleroderma, and polymyositis. Its manifestations are therefore protean, and the recognition of rare presentations of MCTD can enable an early diagnosis.

Alarcon-Segovia  DCardiel  MH Comparison between 3 diagnostic criteria for mixed connective tissue disease: study of 593 patients. J Rheumatol. 1989;16328- 334
Furuya  TSuzuki  TOnoda  N  et al.  Mixed connective tissue disease associated with protein-losing enteropathy: successful treatment with intravenous cyclophosphamide therapy. Intern Med. 1992;311359- 1362
Link to Article[[XSLOpenURL/10.2169/internalmedicine.31.1359]]
Kimura  KEzoe  KYokozeki  HKatayama  INishioka  K Elevated serum CA125 in progressive systemic sclerosis with pleural effusion. J Dermatol. 1995;2228- 31
Amigues  JMCantagrel  AAbbal  MMazieres  B Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. J Rheumatol. 1996;232055- 2062
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Figure 1.

Distal tapering and dry gangrene affecting the fingers of a patient.

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Figure 2.

Arrow indicates a large fibrin mass attached to the atrial aspect of the mitral valve of a patient.

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