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Severe Hyponatremia Induced by Theophylline and Trimethoprim

Jacob Dreiher, MD; Avi Porath, MD, MPH
Arch Intern Med. 2001;161(2):291-292. doi:.
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Hyponatremia is a common adverse effect of many drugs (diuretics, antipsychotic agents, carbamazepine, and others). Among the uncommon causes of hyponatremia are theophylline and trimethoprim. We describe a woman who presented with severe symptomatic hyponatremia following treatment with anhydrous theophylline and developed trimethoprim-induced severe hyponatremia 6 months later.

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