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The Relation Between p70S6k Expression in Lymphocytes and the Decline of Cognitive Test Scores in Patients With Alzheimer Disease

Marc Paccalin, MD; Stéphanie Pain-Barc, PharmD, PhD; Claudette Pluchon, MA; Chloé Paul, MA; Hélène Bazin, MA; Roger Gil, MD; Jacques Hugon, MD, PhD
Arch Intern Med. 2005;165(20):2428-2429. doi:10.1001/archinte.165.20.2428.
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Memory disturbances are one of the first clinical signs detected in patients with Alzheimer disease (AD). The control of protein translation, including the kinases mTOR (mammalian target of rapamycin) and p70S6k, participates in explicit memory formation. Peripheral lymphocytes have impaired metabolism in AD.1 Our group recently reported a significant decrease of activated p70S6k expression in lymphocytes of patients with AD compared with control individuals.2 We report herein a significant correlation between activated p70S6k expression and long-term and working memory and language alterations.

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Significant correlation of the expression of p70S6k in lymphocytes of patients with Alzheimer disease with cognitive tests, including the Gröber and Buschke test (P<.05) (A); the oral denomination 80 test (P<.05) (B); and the reverse digit span test (P<.01) (C).

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