Second malignant neoplasms in long-term survivors of cancers are sometimes encountered.1,2 Although most second malignant neoplasms are treatment related, their occurrence may also be due to an underlying systemic disease or chromosomal abnormalities shared by multiple organs, in which they are potentially tumorigenic. Many cases of acute leukemia as a second malignant neoplasm have been reported after the treatment of initial cancers.3,4 However, cases of acute promyelocytic leukemia after a short interval following leiomyosarcoma have not been reported before to our knowledge. Herein, a Japanese patient who presented with the rare combination of acute promyelocytic leukemia and leiomyosarcoma of the jejunum is described.
A 51-year-old man was referred to the Department of Internal Medicine at the Matsushita Memorial Hospital, Osaka, Japan, on October 25, 1996, because of nasal bleeding and leukocytosis. The patient presented with a large abdominal tumor in April 1995. Laboratory studies on initial admission disclosed normal