Resolution of a Soft-Tissue Sarcoma in a Patient With Rheumatoid Arthritis After Discontinuation of Azathioprine Therapy

M. E. Csuka, MD; Gerald A. Hanson, MD
Arch Intern Med. 1996;156(14):1573-1576. doi:10.1001/archinte.1996.00440130123013.
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An 85-year-old woman with rheumatoid arthritis that was treated with azathioprine presented with a posterior thoracic soft-tissue mass. A computed tomographic scan demonstrated a large mass in the chest wall that extended into the pleural space and several pulmonary nodules that were consistent with metastatic disease. A fine-needle biopsy was performed, and a morphologic diagnosis of sarcoma was made. As the patient was relatively asymptomatic and the lesion was inaccessible to a surgical procedure, no therapy was recommended. Therapy with azathioprine was discontinued. One year later, the mass had resolved. To our knowledge, this is the first reported case of a soft-tissue sarcoma complicating azathioprine treatment of rheumatoid arthritis.

Arch Intern Med. 1996;156:1573-1576


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