0
ARTICLE |

N-Acetylcysteine Inhibits Production of Tumor Necrosis Factor a and Interleukin-1ß

Pedro Redondo, MD; Maria Luisa Subira, MD
Arch Intern Med. 1996;156(11):1238-1241. doi:10.1001/archinte.1996.00440100136017.
Text Size: A A A
Published online

The inhibition of the proinflammatory cytokine tumor necrosis factor a (TNF-α) is considered an essential factor in the treatment of diseases as diverse as multiple sclerosis, rheumatoid arthritis, Crohn disease, systemic lupus erythematosus, and some forms of diabetes, as well as other diseases that involve selective immunologic attack on a particular organ or system.1 In autoimmune disease, interleukin-1 (IL-1) acts by stimulating other cells to produce cytokines or enzymes that then act on the target tissue.2 In addition, TNF-α can stimulate the production of IL-1; hence, both molecules are likely to be involved in the pathogenesis of septic shock and other diseases. The cytokines IL-1β and TNF-α are often grouped together and called proinflammatory cytokines. The biochemical changes induced by TNF-α and IL-1β include increased synthesis of nitric oxide and endothelial cell adhesion molecules. Once TNF-α and IL-1β are secreted, the cascade of inflammation erupts with secondary secretion

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 13

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();