HANTAVIRUSES CAUSE chronic infections of rodents and occasionally infect other species as well. Several of the Old World viruses are well known as causes of hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Although HFRS has rarely been described in the United States,1 it is assumed to be underreported. In 1993, an outbreak of febrile disease resembling adult respiratory distress syndrome occurred in the southwestern United States and was found to be caused by a new hantavirus, Sin Nombre virus.2
The unique pulmonary syndrome (hantavirus pulmonary syndrome [HPS]) differed from the renal disease so prominent in HFRS. Immunohistologic studies provide evidence of compartmentalization of a selective immune response in the lung in combination with large amounts of viral antigens in the pulmonary microvasculature.3 Detailed mechanisms of pathogenesis are not understood, although there are some similarities to HFRS.4 Selective inflammatory cell recruitment to the lung may occur
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 4
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.