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Use of Bartonella Antigens for Serologic Diagnosis of Cat-scratch Disease at a National Referral Center

Mary Jane Dalton, MD; Laura E. Robinson, DVM; Judy Cooper, MS; Russell L. Regnery, PhD; James G. Olson, PhD; James E. Childs, ScD
Arch Intern Med. 1995;155(15):1670-1676. doi:10.1001/archinte.1995.00430150164017.
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Background:  Bartonella henselae (formerly the genus Rochalimaea) has recently been isolated from patients with cat-scratch disease and their cats, and since September 1992 the Centers for Disease Control and Prevention has offered an indirect fluorescent antibody assay for Bartonella-specific antibody.

Methods:  Physicians submitted serum samples from patients suspected of having cat-scratch disease or other Bartonella-associated illness and completed a questionnaire that recorded clinical information. Indirect fluorescent antibody assay was performed with the use of antigen derived from three Bartonella species: B henselae, Bartonella quintana, and Bartonella elizabethae.

Results:  During 16 months, 3088 serum samples were received. The largest numbers of specimens and the highest percentages positive (titer, ≥64) were observed in the fall and winter. Clinical histories of the first 600 patients for whom serum samples and completed information forms were received were examined in detail; seropositivity was significantly associated with cat contact, cat age of less than 1 year, cat scratch, presence of an inoculation papule, and regional adenopathy. Of 91 patients whose illness met a strict clinical definition of cat-scratch disease, 86 (95%) had titers of 64 or greater to either B henselae or B quintana. A fourfold rise or fall in titer was observed in 87 of 132 patients with paired serum samples.

Conclusions:  The indirect fluorescent antibody assay forBartonella-specific antibody is sensitive for the diagnosis of cat-scratch disease. Redefinition of cat-scratch disease on the basis of cause and use of this assay as a diagnostic criterion is recommended.(Arch Intern Med. 1995;155:1670-1676)


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