0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Prevalence and Correction of Hypothyroidism in a Large Cohort of Patients Referred for Dyslipidemia

Theo Diekman, MD; Peter J. Lansberg, MD, PhD; John J. P. Kastelein, MD, PhD; Wilmar M. Wiersinga, MD, PhD
Arch Intern Med. 1995;155(14):1490-1495. doi:10.1001/archinte.1995.00430140052004.
Text Size: A A A
Published online

Background:  Treatment of hypercholesterolemia can reduce the risk of developing premature atherosclerosis. The hypercholesterolemia caused by hypothyroidism is potentially reversible by thyroid hormone replacement therapy. We determined the prevalence of hypothyroidism in patients referred to a university lipid research clinic and studied the changes in lipid and lipoprotein levels on restoration of the euthyroid state.

Methods:  A retrospective follow-up study was performed. In all 1509 consecutive referrals for severe dyslipidemia, thyrotropin levels were measured. Patients with hypothyroidism were identified by means of a computed database, from January 1, 1989, to July 1, 1993, first by levothyroxine sodium medication and second by serum thyrotropin values greater than 5 mU/L. Twenty-one patients were available to evaluate the effect of restoration of the euthyroid state on plasma lipid and lipoprotein levels.

Results:  The observed prevalence of hypothyroidism proved to be 4.2% (64/1509). The disorder was previously known in 25 patients and newly diagnosed in 39 patients (11 with overt hypothyroidism and 28 with subclinical hypothyroidism). Significant reductions in total cholesterol and low-density lipoprotein cholesterol levels occurred only in patients with pretreatment thyrotropin values of 10 mU/L or more.

Conclusions:  The prevalence of newly diagnosed cases of overt hypothyroidism in patients referred to a lipid clinic is approximately two times that in the general population. The absence of significant reductions in total cholesterol and low-density lipoprotein cholesterol levels on levothyroxine treatment in patients with minor subclinical hypothyroidism (thyrotropin level, <10 mU/L) does not support the view that this condition is a risk factor for atherosclerosis mediated by an elevated low-density lipoprotein cholesterol level. All patients referred for diagnosis and treatment of dyslipidemia should be screened for hypothyroidism by measurement of thyrotropin values.(Arch Intern Med. 1995;155:1490-1495)

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 57

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();