We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Has the Cost-effectiveness of Misoprostol Been Underestimated?-Reply

Gerold Stucki, MD, MS; Magnus Johannesson, PhD; Matthew H. Liang, MD, MPH
Arch Intern Med. 1995;155(13):1451-1452. doi:10.1001/archinte.1995.00430130142018.
Text Size: A A A
Published online


In reply  We appreciate the comments of Fort and Hoffmann and Gabriel. Fort and Hoffmann state that misoprostol is indicated for nonsteroidal anti-inflammatory drug (NSAID) users with risk factors such as advanced age, history of peptic ulcer disease, and comorbid conditions, but its promotion and perceived indications are not as conservative. For instance, in the current issue of Drug Information for Physicians in Switzerland,1 no mention of these risk factors is made.The combination of misoprostol and a NSAID in fixed doses may increase compliance, but there are disadvantages as well. In patients with rheumatic diseases, the clinically effective dose and the time of administration for NSAIDs vary. With the use of fixed combinations, the effective and minimally necessary dose cannot be adjusted with the same caution as with single drugs. Our review was not about the rational use of misoprostol; it was about the evidence with regard to


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

2 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.