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Paroxetine-Induced Priapism

Saeed Ahmad, MD, FRCP
Arch Intern Med. 1995;155(6):645. doi:10.1001/archinte.1995.00430060109017.
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Paroxetine is a new antidepressant that, like fluoxetine, is a serotonin antagonist. We report a case of side effects that developed after treatment with paroxetine.

Report of a Case.  A 58-year-old man developed priapism following treatment with paroxetine (20 mg daily) for his depression. He presented with a 42-hour history of a continuous and painful erection. When it was determined that he did not need a spongiocavernous shunt, the paroxetine was replaced with venlafaxine.

Comment.  The patient made a complete recovery over the next 8 hours. The patient refused to be challenged, although it appears that priapism was associated with paroxetine therapy. This side effect has not been previously described.


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