We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Cholesterol and Violent Behavior

Michael E. Serjeant, MB, ChB
Arch Intern Med. 1995;155(5):544. doi:10.1001/archinte.1995.00430050124016.
Text Size: A A A
Published online


In their recent article,1 Santiago and Dalen focus on the intriguing relationship between low cholesterol levels and violence. They note that Muldoon and colleagues2 suggested that lowering the cholesterol level might trigger behavioral, affective, or nervous system changes, and they, additionally, proposed the use of serotonin as an intermediary. Supporting evidence for this neurotransmitter, however, is meager, which is not surprising as serotonin is more associated with suicide related to depression than with violence.

However, the latter is suggestive of increased sympathoadrenal activity, for which there is evidence. As cholesterol is essential for steroid production, reduced availability should result in a negative feedback response involving its tropic hormone, adrenocorticotropin, for which supporting statistics exist.2 Furthermore, in amphibians, cholesterol itself has been shown to downregulate hypothalamo-pituitary-adrenal activity,3 establishing at least a regulatory role in vertebrates.

Finally, a more basic point. Survival requires that a falling level of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.