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Severe Episode of High Fever With Rash, Lymphadenopathy, Neutropenia, and Eosinophilia After Minocycline Therapy for Acne

Dagmar Kaufmann, MD; Werner Pichler, MD; Jürg H. Beer, MD
Arch Intern Med. 1994;154(17):1983-1984. doi:10.1001/archinte.1994.00420170135014.
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Minocycline is a tetracycline agent frequently used for acne therapy. It has a few rare but severe side effects that are not widely known but should be recognized early as drug related. These include acute hepatitis and liver failure1,2; a Löfflerlike syndrome with pulmonary infiltrates, wheezing, fever, and eosinophilia3,4; skin eruptions, eosinophilic cellulitis, and pustular folliculitis with eosinophilia5; and a lupuslike syndrome.6 Side effects that are better known and recognized include photosensitization, skin exanthema with pruritus, and pseudotumor cerebri.

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