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Invasive Sinusitis With Intracranial Extension Caused by Curvularia lunata

Yahya Ismail, MD; Royce H. Johnson, MD; Michael V. Wells, MD; James Pusavat, MT(ASCP), SM; Kelvin Douglas, MD; Edward L. Arsura, MD
Arch Intern Med. 1993;153(13):1604-1606. doi:10.1001/archinte.1993.00410130126013.
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Curvularia lunata has previously been linked to localized sinus infection in immunocompetent hosts. We treated a case of pansinusitis with extensive bone destruction and intracranial extension caused by C lunata. Curvularia lunata was identified when typical fungal macroconidia appeared on culture. Numerous surgical procedures, in addition to a 12-month course of antifungal therapy consisting of 4 g of intravenous amphotericin B and an 8-month course of 400 mg of oral ketoconazole daily, were required to control the infection. This unusual case of invasive sinusitis caused by C lunata alerts the treating physician to the presence of this mold and gives an overview of diagnostic method as well as the management.

(Arch Intern Med. 1993;153:1604-1606)


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