Captopril and the Effect of Interferon Gamma on Monocytes

Mikhail Samsonov, MD; Gabriele Werner-Felmayer, PhD; Dietmar Fuchs, PhD; Eugeney Nassonov, MD; Helmut Wachter, PhD
Arch Intern Med. 1993;153(9):1138-1142. doi:10.1001/archinte.1993.00410090080013.
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Captopril is used as an antihypertensive drug for its inhibiting effect on angiotensin-converting enzyme, the enzyme that converts inactive angiotensin I to the active vasopressor angiotensin II. Captopril has also been shown to induce immunosuppression by a mechanism that involves monocytes and CD8+ cells. In vivo, captopril was beneficial in patients with rheumatoid arthritis2 and in an animal model of systemic lupus erythematosus.3

To study whether captopril has any direct effects on cells of the monocyte/macrophage lineage, we tested its influence on formation of neopterin, an in vivo marker for immune activation,4 and on tryptophan degradation. Both biochemical pathways are induced by interferon gamma in macrophages.5 We used the human myelomonocytic cell line THP-1 (American Type Culture Collection, Rockville, Md) that behaves similarly in this respect to freshly isolated monocytes.6 Cells grown in RPMI 1640 containing 10% heat-inactivated fetal calf serum, 2 mmol/L of L-glutamine,


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