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Human Herpesvirus Type 6 and Chronic Fatigue Syndrome

Paul H. Levine, MD; Anthony L. Komaroff, MD
Arch Intern Med. 1993;153(5):661. doi:10.1001/archinte.1993.00410050089012.
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We have each been the senior author of separate, recently published articles, one in the August 1992 issue of the Archives1 and another in the January 15, 1992, issue of the Annals of Internal Medicine,2 involving tests for human herpesvirus type 6 (HHV-6) in patients living in the Lake Tahoe region of California who developed an illness resembling the chronic fatigue syndrome. Questions have arisen regarding how the two articles relate to one another.

The primary purpose of the article in the Archives was to document the heterogeneity of clusters variously designated as epidemic neuromyasthenia, epidemic chronic fatigue syndrome, or other condition. This article also described the long-term outcome in those individuals, and a search for evidence of retrovirus infection, which proved to be negative. As part of the study reported in the Archives, antibody titers to HHV-6 were determined in 27 patients.

The primary purpose of the


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