Association of Fasting Insulin With Blood Pressure in Young Individuals:  The Bogalusa Heart Study

Xiaozhang Jiang, MD; Sathanur R. Srinivasan, PhD; Weihang Bao, PhD; Gerald S. Berenson, MD
Arch Intern Med. 1993;153(3):323-328. doi:10.1001/archinte.1993.00410030037006.
Text Size: A A A
Published online

Background:  The relationship between fasting plasma insulin and blood pressure was studied in a cross-sectional survey of children and young adults aged 5 to 26 years.

Methods:  Fasting plasma insulin, glucose, blood pressure, and anthropometric measurements were obtained on 3518 individuals.

Results:  When divided into four age groups, the analyses showed that fasting insulin was significantly and positively correlated to both systolic and diastolic blood pressure in individuals at all age groups, except at 13 to 17 years. In multivariate regression analyses, fasting insulin remained independently associated with blood pressure levels after controlling for glucose levels, body mass index (weight/height2) and skinfold thickness in children (aged 5 to 12 years) and young adults (aged 18 to 26 years), although not in adolescents (aged 13 to 17 years). Moreover, fasting insulin was more strongly related to systolic than to diastolic blood pressure. The fasting blood glucose level did not contribute independently to multivariate prediction of blood pressure in young adults. When the children and young adults were divided into tertiles according to fasting insulin and body mass index, the independent effect of insulin and body mass index on systolic pressure was also seen in children and young adults.

Conclusions:  The association between plasma insulin and blood pressure noted even in healthy children and young adults help target areas for cardiovascular risk prevention.(Arch Intern Med. 1993;153:323-328)


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 53

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.