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Report on Other Drug Use Among Persons Previously Reported to Have Received Intravenous Cimetidine

Hershel Jick, MD
Arch Intern Med. 1992;152(10):2145. doi:10.1001/archinte.1992.00400220145034.
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To the Editor.—  In 1986, we1 published the results of an intensive monitoring study for drug toxicity in 1189 patients who received intravenous cimetidine while in the hospital. In that series, we noted one reported case of a drug interaction leading to an adverse effect. This was in a patient who developed a prolonged prothrombin time while receiving both warfarin and cimetidine. After cimetidine treatment was stopped, the prothrombin time returned to normal.1Since our prior publication,1 numerous potential drug interactions with cimetidine have been discussed.2 In this regard, we have reviewed our study results. Among the 1189 recipients of intravenous cimetidine, there were 166 subjects who received theophylline-containing preparations, 31 who received phenytoin, 66 who received lidocaine, 238 who received diazepam, 107 who received digoxin, 11 who received nifedipine, 45 who received propranolol, 199 who received furosemide, and 25 subjects who received amitriptyline. Among patients


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