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Serum Thyrotropin Levels and Adrenotoxicosis-Reply

Ingmar Skoog, MD; Görel Sundbeck, MD; Staffan Edén, MD; Rudolf Jagenburg, MD; Göran Lindstedt, MD
Arch Intern Med. 1992;152(10):2143-2144. doi:10.1001/archinte.1992.00400220143031.
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In Reply.—  For reasons of brevity, in our previous response1 to Serjeant we did not detail the procedures used in the psychiatric evaluation of our 85-year-old subjects. A systematic subsample (494 individuals, in 86% of whom thyroid evaluation could be done [in 285 women and 152 men]) underwent a structured psychiatric examination, which was supplemented with a detailed questionnaire.2 Mental disorders were defined according to the Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised. The examination did not, however, allow a separation of generalized anxiety disorder and panic disorder.Ten of our 18 subjects with a serum thyrotropin concentration of less than 0.20 mU/L, in one of whom a hyperthyroid condition was diagnosed, were included in the systematic subsample. In none of these subjects was a diagnosis of generalized anxiety disorder/panic disorder (GAD/PD) established, whereas in 5.5% of the total population sample GAD/PD was diagnosed (note that


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