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Comparison of Gemfibrozil and Lovastatin in Patients With High Low-Density Lipoprotein and Low High-Density Lipoprotein Cholesterol Levels

James M. McKenney, PharmD; Michael D. Barnett, PharmD; Jackson T. Wright Jr, MD, PhD; Jack P. Proctor, MD
Arch Intern Med. 1992;152(9):1781-1787. doi:10.1001/archinte.1992.00400210023005.
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Background.—  The efficacy of gemfibrozil and lovastatin in the treatment of patients who have an elevated low-density lipoprotein cholesterol (LDL-C) level and a low high-density lipoprotein cholesterol (HDL-C) level was compared.

Methods.—  After at least 6 weeks of a choleserol-lowering diet, 17 patients who had a mean baseline LDL-C level above 4.14 mmol/L (160 mg/dL) and an HDL-C level below 1.03 mmol/L (40 mg/dL) received gemfibrozil 600 mg twice daily and lovastatin 20 mg twice daily each for 6 weeks according to a randomized, crossover, double-blind research design.

Results.—  Lovastatin and gemfibrozil reduced LDL-C levels 34% and 9% and raised HDL-C levels 15% and 18%, respectively.

Conclusions.—  Lovastatin is more effective in lowering LDL-C levels and is as effective as gemfibrozil in increasing HDL-C levels in these patients.(Arch Intern Med. 1992;152:1781-1787)


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