To review limitations of the use of serum anion gap in clinical practice.
Original reports and reviews.
Sources containing the most recent pertinent information.
Theoretical and practical limitations beset the use of serum anion gap. Awareness of these limitations reduces but does not eliminate wrong diagnoses based on the anion gaps.
Serum anion gap has a limited value in the differential diagnosis of acid-base disorders and can be misleading.(Arch Intern Med. 1992;152:1625-1629)