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Article |

An Acquired Hemorrhagic Disorder From Long-Acting Rodenticide Ingestion

Glenn S. Ross, MD; Leo R. Zacharski, MD; Donna Robert, MT(ASCP)SH; David L. Rabin, MD
Arch Intern Med. 1992;152(2):410-412. doi:10.1001/archinte.1992.00400140146031.
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A 62-year-old man who presented with gross hematuria was found to have a severe and prolonged coagulopathy. The workup involved mixing studies, which suggested an acquired factor deficiency, and specific factor assays, which demonstrated isolated defects in vitamin K—dependent factors. With vitamin K deficiency excluded, and serum warfarin levels undetectable, so-called superwarfarin ingestion was suspected. This diagnosis was subsequently proved by biochemical evidence (an increase in the serum vitamin K epoxide—vitamin K ratio) and compatible history. This case illustrates how a logical workup can lead to a diagnosis of superwarfarin ingestion, even without a history of such an ingestion. New serum assays for specific superwarfarins are also mentioned. This case report should increase clinicians' awareness of long-acting rodenticide ingestions.

(Arch Intern Med. 1992;152:410-412)


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