1,1,1-Trichloroethane and the Liver

Philip S. Guzelian, MD
Arch Intern Med. 1991;151(11):2321-2322. doi:10.1001/archinte.1991.00400110145035.
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To the Editor.—  The recent article by Hodgson et al1 raised a new and potentially important conclusion. Based on the four cases presented, it is the authors' opinion that 1,1,1 -trichloroethane (TCA), a widely used industrial solvent "... not considered to have hepatotoxic potential...," should "... be reconsidered as an agent with potential hepatotoxicity in man." The authors believe that failure of the scientific and medical communities to recognize the toxic effects of occupational exposure to this agent on the liver may be due to misdiagnoses, infrequency of occurrence, and lack of case-control methodology in epidemiologic studies of worker populations, among several possibilities. However, as a consultant in liver disease and toxicology, I have had an opportunity to independently review the complete medical records and ancillary information on two of the four cases reported by Hodgson et al and I have found significant inaccuracies and omissions in the presented data, which


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