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The Significance of Low Serum Thyrotropin in the Elderly-Reply

Görel Sundbeck, MD; Rudolf Jagenburg, MD; Staffan Edén, MD; Göran Lindstedt, MD
Arch Intern Med. 1991;151(11):2318. doi:10.1001/archinte.1991.00400110144032.
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In Reply.—  We appreciate Serjeant's interest in our work1 and his suggestions as to the cause(s) of low serum thyrotropin concentration in nonhyperthyroid individuals. Indeed, with the background that patients with psychiatric disorders may display abnormal serum thyrotropin concentrations, low or high, we had carefully examined our probands and also their medical records for such disorders. In addition, about half of the study population (285 women and 152 men) had been examined by a specialist in psychiatry (Ingemar Skoog, Department of Psychiatry, University of Göteborg [Sweden]).There was no evidence for panic disorder in any of the 18 probands with a serum thyrotropin concentration lower than 0.20 mU/L who were not receiving thyroid hormone treatment. Of the 10 probands taking part in the specialist psychiatric evaluation (nine women), five had no psychiatric disorder, whereas three had an anxiety disorder (DSM-III criteria). Of 407 individuals without present or past thyroid


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