To determine if perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) might be associated with increased postoperative morbidity.
Patients and Methods.—
Records from 165 patients undergoing total hip arthroplasty from 1984 to 1987 were reviewed. Patients taking NSAIDs at hospital admission were compared with those who were not.
Patients taking NSAIDs had more postoperative bleeding complications (gastrointestinal tract bleeding and/or hypotension) than did patients not taking those agents. Complications were more frequent in patients using NSAIDs with half-lives longer than 6 hours.
Patients undergoing elective surgery should stop taking NSAIDs in time to allow elimination of the drug; those patients who need to take these agents perioperatively should use drugs with short half-lives.(Arch Intern Med. 1991;151:1963-1966)