We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Influence of Low-Intensity Warfarin Treatment on Patients' Perceptions of Quality of Life

Jack Hirsh, MD
Arch Intern Med. 1991;151(10):1921-1922. doi:10.1001/archinte.1991.00400100009001.
Text Size: A A A
Published online


The popularity of warfarin, a drug that has been in clinical use for approximately 50 years, has waxed and waned and is currently on the rise. The recent interest in clinical use has been stimulated by the observation that less intense warfarin regimens are as effective as, but produce much less bleeding than, the high-intensity regimens that were standard in North America in the past. Thus, results of randomized trials have demonstrated that low-intensity regimens are as effective as, but much safer than, high-intensity regimens for the treatment of venous thrombosis and for the prevention of systemic embolism in patients with tissue heart valves and, more recently, in patients with mechanical heart valves1-3 (Table). These findings provided the impetus for clinical trials assessing the relative risks and benefits of low-intensity warfarin in patients with nonvalvular atrial fibrillation.4,5 The results have been impressive—a greater than 60% risk reduction in


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

13 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.