Nocturnal Cramps, Quinine, and Thrombocytopenia

Ian W. Boyd, BSc, PhD
Arch Intern Med. 1991;151(5):1021. doi:10.1001/archinte.1991.00400050151033.
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To the Editor.—  I read with some interest the article by McGee,1 regarding muscle cramps. Of particular note was the discussion on the use of quinine for the treatment of nocturnal cramps. While not wishing to comment further on the efficacy of quinine, I would like to point out McGee's comment that "it is on the meager weight of this scientific evidence and single-blind testimonies that quinine remains the most recommended drug for muscle cramps," because there is a need for some further discussion on the adverse effects of this drug.The Adverse Drug Reactions Section of the Australian Therapeutic Goods Administration receives voluntary reports on suspected adverse reactions to drugs, forwarded by medical practitioners, hospitals, pharmacists, dentists, and other health professionals. These are reviewed by The Australian Adverse Drug Reactions Advisory Committee, a subcommittee of the Australian Drug Evaluation Committee. The Australian Adverse Drug Reactions Advisory Committee has


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