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Unrecognized Drug Interactions With Famotidine and Nizatidine

Arthur F. Shinn, PharmD
Arch Intern Med. 1991;151(4):814. doi:10.1001/archinte.1991.00400040140035.
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To the Editor.—  After reading the recent article by Lipsy et al1 in the April 1990 issue of the Archives, I felt it appropriate to respond specifically to the section of this article pertaining to drug interactions. It is the purpose of this letter to report on the results of my investigation into several events that had been previously submitted to the United States Food and Drug Administration's (FDA) Spontaneous Adverse Drug Reaction Reporting System.Lipsy and his colleagues state that nizatidine interactions have not been explored and that to date no documented drug interactions have been reported between famotidine and diazepam, phenytoin, procainamide hydrochloride, theophylline, and warfarin sodium.Under the Freedom of Information Act, I obtained several reports for nizatidine (Axid) and famotidine (Pepcid), which had been entered into the FDA Spontaneous Adverse Drug Reaction Database during the period of each product's initial marketing in the United States


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