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Unrecognized Drug Interactions With Famotidine and Nizatidine

Robyn G. Karlstadt, MD; Robert H. Palmer, MD
Arch Intern Med. 1991;151(4):810-814. doi:10.1001/archinte.1991.00400040140034.
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To the Editor.—  We read the article by Lipsy et al1 with great interest and concern regarding errors in the information presented. In our opinion, the article was not objective or balanced. Because of space limitation, we will comment on only a few issues.The authors claim that ranitidine is thought to cause less confusion than cimetidine. We are unaware of any studies supporting this statement. There is at least one study2 that reviewed the incidence of adverse effects in a hospital population receiving intravenous cimetidine; it is the only one we are aware of in which incidence was looked at. In fact, Haug et al3 reported a fairly high incidence of central nervous system adverse events in a group of patients with renal failure receiving ranitidine. In addition to the cases reported by Lipsy et al, there are at least two cases where mental confusion was not


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