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Cyclic Antidepressants and the Risk of Hip Fracture

Wayne A. Ray, PhD; Marie R. Griffin, MD, MPH
Arch Intern Med. 1991;151(4):754-756. doi:10.1001/archinte.1991.00400040096021.
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To determine whether cyclic antidepressants increase the risk of hip fracture, we conducted a population-based casecontrol study in the Canadian province of Saskatchewan. We identified 4501 persons 65 years of age or older with a first hospitalization for hip fracture between 1977 and 1985 and 24 041 comparable controls. Current antidepressant users had a relative risk of hip fracture of 1.6 (95% confidence interval, 1.3 to 1.9). Medical record review for a sample of 164 cases suggested this finding was not due to confounding by body mass, impaired ambulation, functional status, or dementia.

(Arch Intern Med. 1991;151:754-756)


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