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Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction

Ellen F. Binder, MD; Lillibeth Cayabyab; David J. Ritchie, PharmD; Stanley J. Birge, MD
Arch Intern Med. 1991;151(2):373-374. doi:10.1001/archinte.1991.00400020119023.
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Calcium channel blockers are being used increasingly for a variety of cardiovascular problems. Diltiazem hydrochloride, a benzothiazepine derivative, has been reported to have a low incidence of adverse side effects. We report a case of acute psychosis associated with the use of diltiazem in a patient receiving lithium carbonate therapy. Both diltiazem hydrochloride and lithium carbonate have calcium antagonist effects in the central nervous system, and we review their mechanisms of action. A possible synergistic drug interaction between diltiazem and lithium is reported.

(Arch Intern Med. 1991;151:373-374)


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