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Rapid Correction of Hypokalemia: A Note of Caution-Reply

James A. Kruse, MD; Richard W. Carlson, MD, PHD
Arch Intern Med. 1991;151(1):203. doi:10.1001/archinte.1991.00400010183040.
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In Reply—  Dr Spital makes a plea for more data demonstrating the serum potassium response during potassium chloride infusions. It is conceivable that transient hyperkalmia could occur at the end of an infusion period and resolve prior to obtaining a postinfusion serum potassium measurement. However, since the chief danger of transient hyperkalemia is ventricular tachyarrhythmia, it is reassuring that there were no instances of such rhythm disturbances occurring during the infusion periods in our study1 population. Nevertheless, we agree that it would be enlightening to know the serum potassium response during these infusions, as well as to have a more sensitive indicator of possible electrophysiologic effects short of ventricular tachycardia. To this end, we are currently completing a prospective clinical study investigating the pharmacokinetic effects of potassium infusions identical to those selected in our retrospective study. By performing potassium measurements every few minutes during and after the infusion and


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