ß-Blockers and Cimetidine

Arch Intern Med. 1990;150(6):1348. doi:10.1001/archinte.1990.00390180146030.
Text Size: A A A
Published online

To the Editor.—The publication of the 1988 report from the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure1 presents an updating of a consensus among its members with regard to the treatment of essential hypertension in a concise and comprehensive fashion.

However, I believe that a serious error is contained in the report that may affect the treatment of a large number of patients. In particular, I refer to Table 5. Under β-blockers it is stated that "cimetidine may reduce the bioavailability of β-blockers metabolized primarily by the liver by inducing hepatic oxidative enzymes." In fact, the exact opposite of this statement is well accepted by clinical pharmacologists throughout the world. Cimetidine is known to inhibit hepatic oxidative enzymes of the cytochrome P-450 system, thus increasing the bioavailability of hepatically oxidized β-blockers and serum concentrations of these drugs.2

A pharmacokinetic interaction between cimetidine and


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.