Leptospirosis as a Cause of Uveitis

George Watt, MD, DTM&H
Arch Intern Med. 1990;150(5):1130. doi:10.1001/archinte.1990.00390170152044.
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To the Editor.—Although Rosenbaum showed clearly that an evaluation for systemic disease in a patient with uveitis is useful, no specific diagnosis could be made in a quarter of his patients. The cause remained undefined in over half the patients reported in another large study.2 Adding leptospirosis to the list of causes of uveal tract inflammation could perhaps improve the ability to determine a specific cause. This disease remains a major public health problem in parts of the developing world, and is frequently underdiagnosed in the United States: in one series only 17% of 483 proven cases were initially thought to be leptospirosis.3 The precise incidence of uveitis in leptospirosis is unknown, but has been reported to range from 10% to 44%.4 The anterior uveal tract is usually affected 4 to 8 months after initial disease symptoms appear, at a time when other clinical features have


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