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Intravenous Nicardipine for the Treatment of Severe Hypertension A Double-blind, Placebo-Controlled Multicenter Trial

J. David Wallin, MD; Eugene Fletcher, MD; C. Venkata S. Ram, MD; M. Eileen Cook, MD; Deanna G. Cheung, MD; E. Paul MacCarthy, MD; Raymond Townsend, MD; Elijah Saunders, MD; W. Ross Davis, MD; Herbert G. Langford, MD; George DeVault, MD; Walter Flamenbaum, MD; Gray Ellrodt, MD; Bruce Hamilton, MD; Stuart Frank, MD; William Frishman, MD
Arch Intern Med. 1989;149(12):2662-2669. doi:10.1001/archinte.1989.00390120034008.
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• A placebo-controlled, double-blind multicenter trial was conducted in 123 patients with severe hypertension to examine the efficacy and safety of intravenously administered nicardipine hydrochloride in controlling blood pressure. Seventy-three patients were initially randomized to receive nicardipine treatment. This group had an initial blood pressure of 213±3/126±2 mm Hg. Sixty-seven patients achieved the therapeutic goal (diastolic blood pressure 95 mm Hg; systolic blood pressure ≤160 mm Hg). Fifty patients were randomized to receive placebo solution. Blood pressure in these patients was 216±3/125±2 mm Hg. No patient in this group achieved the therapeutic goal during the "blinded" portion of the study. Forty-four of 49 patients who did not respond to placebo administration responded to subsequent treatment with nicardipine. Patients with end-organ damage were included in the study. These included patients with left ventricular hypertrophy, retinopathy, and renal insufficiency. Patients with and without end-organ damage responded equally well to nicardipine treatment. Serious adverse experiences were infrequent, the most common adverse reaction being headache in 24% of the patients studied.

(Arch Intern Med. 1989;149:2662-2669)


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