To the Editor.—Two types of acquired angioedema (AAE) are recognized today; type I with low levels of functional C1-inhibitor (C1-INH), no detectable autoantibody to C1-INH, and an underlying disease, such as a B-cell disorder,1 and type II with moderately depressed functional C1-INH levels, anti–C1-INH autoantibodies in circulation without detectable underlying disease.2-4 We describe the long-term follow-up of a patient with AAE type II.
Report of a Case.—A woman, born in 1921, first presented with an attack of angioedema in December 1980. Based on complement studies and patient history, an AAE was diagnosed in December 1981. Therapy with danazol and later with tranexamic acid was initiated. Recurrent life-threatening attacks with need for the infusion of fresh frozen plasma indicated ineffectiveness of these therapies. Several investigations failed to detect a malignant neoplasia or a dysproteinemia. However, in August 1983, a giant subserous myoma of the fundus of the
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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