Clinical Manifestations of Human Parvovirus B19 in Adults

Anthony D. Woolf, MRCP; Giles V. Campion, MRCP; Alice Chishick, MBChB; Stephen Wise, MRCP; Bernard J. Cohen, PhD; Peter T. Klouda, PhD; Owen Caul, PhD; Paul A. Dieppe, FRCP
Arch Intern Med. 1989;149(5):1153-1156. doi:10.1001/archinte.1989.00390050111022.
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• Human parvovirus B19 has been associated with various clinical effects in a number of uncontrolled reports. To define the usual manifestations of B19 infection in adults and the factors that influence them we present a clinicoepidemiological study of an outbreak of B19 infection centered on a junior school. Four hundred fifty-three of 475 adults in this community were interviewed and blood was obtained for serological diagnosis. Fifty-four cases of recent infection were identified and were HLA typed. Fourteen of the cases were asymptomatic; 32 had an influenzalike illness; 23 a rash; and 26 an acute-onset polyarthropathy that was more common in women and lasted for up to 7 months. HLA-A, -B, and -C antigen frequencies were similar to a local control population and showed no association with symptoms except that HLA-DR1 was absent in those with persistent arthropathy.

(Arch Intern Med. 1989;149:1153-1156)


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