We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Is Silent Thyroiditis an Autoimmune Disease?

Robert Volpé, MD, FRCPC
Arch Intern Med. 1988;148(9):1907-1908. doi:10.1001/archinte.1988.00380090009003.
Text Size: A A A
Published online


The entity of silent (painless) thyroiditis has been recognized over the past decade as a clinical syndrome manifested by transient hyperthyroidism associated with a marked depression of the thyroidal radioactive iodine uptake, often followed by a transient period of hypothyroidism, but most patients ultimately recover to normal.1 The similarity of the thyroid dysfunction and the evolution during the course of the disease in silent thyroiditis to the picture seen in de Quervain's subacute thyroiditis brought with it the possibility that silent thyroiditis might share a similar cause with de Quervain's thyroiditis, namely, a possible viral infection.1-4 However, a number of elements argue against that possibility.

See also p 1974.

First, the histologic appearance of the thyroid gland in this condition shows lymphocytic infiltration reminiscent of Hashimoto's thyroiditis. It is not identical with typical Hashimoto's thyroiditis, however, since there are few lymphoid follicles, few or no Hürthle cells are


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

19 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.