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ARTICLE |

The Effects of Antihypertensive Agents on Serum Lipids and Lipoproteins

Claude K. Lardinois, MD; Sherry L. Neuman
Arch Intern Med. 1988;148(6):1280-1288. doi:10.1001/archinte.1988.00380060044012.
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• Hypertension is a major risk factor for arteriosclerotic vascular disease. Despite intensive antihypertensive Intervention, the risk of cardiovascular disease has not declined appreciably. Many of the antihypertensive agents have been shown to elevate total serum cholesterol and triglyceride levels or lower the high-density lipoprotein-cholesterol level. Thus, the antihypertensive agents chosen may negate the beneficial effects of a lower blood pressure. Our purpose is to review all available antihypertensive medications and their influence on lipoprotein metabolism. Choosing the antihypertensive therapy least likely to worsen or precipitate other known cardiovascular risk factors is important. Cost and side effect profiles must also be considered in choosing the best antihypertensive regimen for your patients.

(Arch Intern Med 1988;148:1280-1288)

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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