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Characterization of the Acute Clinical Illness Associated With Human Immunodeficiency Virus Infection

Brett Tindall; Steven Barker, MB; Basil Donovan, MB; Timothy Barnes, MB; Jo Roberts; Coralie Kronenberg; Julian Gold, MB; Ronald Penny, DSc; David Cooper, MD; Anthony I. Adams, MD; Geoffrey Berry, PhD; David A. Cooper, MD; Bruce Whyte, MB; Marie Johnson; MaryLouise McLaws, MPH; Michael Perdices, MA; Susan Best; Jennifer Blunt; Pam Borrow; Gralaeme Chapman, PhD; Lindsay Hurren; Allison Imrie; Con Katakouzinos; Susan Kehrer; Helen McCabe; Anne Malcolm; Megan North; Lesley Painter; E. Schreurs, RN; Melita Stevens; Eileen Wilson, MS; R. Wilson, RN; Mark Anns; Duncan Grant; Andrew Morlet; Ross Philpot, MB; Rodney Jones, MB; Joyce Burcham; Timothy G. Barnes, MB; Peter Brooke, MB; Robert Finlayson, MB; Phillip Haynes, MB; Rod Lovett, MB; Harry M. Michelmore, MB; Keiran Mutimer, MB; Ross Price, MB; Clive Wolfe, MB
Arch Intern Med. 1988;148(4):945-949. doi:10.1001/archinte.1988.00380040185026.
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• The clinical and serologic features and immune status of 39 homosexual men who had seroconversion to human immunodeficiency virus positivity were compared with 26 homosexual men who remained seronegative during a six-month period. An acute clinical Illness occurred in 92.3% of seroconverted subjects and 40% of controls. The duration of illness was significantly greater In the seroconverters than the controls (10 + 4.4 days). A general practitioner was consulted by 87.2% of the seroconverters because of the illness, including 12.8% who were admitted to hospital, compared with 20% of controls. The most frequently reported symptoms In the seroconversion group were fever (76.9%); lethargy and malaise (66.7%); anorexia, sore throat, and myalgias (56.4% each); headaches and arthralgias (48.7% each); weight loss (46.2%); swollen glands (43.5%); retro-orbital pain (38.5%); and dehydration and nausea (30.8% each). Lymphadenopathy developed in 75% of seroconverters compared with 4% of controls. Changes in T-cell subsets were not found in controls, but the number of T4 + cells and the T4 + /T8 + ratio decreased significantly in seroconverters.

(Arch Intern Med 1988;148:945-949)

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